Config File Not Valid JSON

That’s not valid JSON.
A json objects start with { and end with }
e.g.

{
  "mail": {
                "transport": "test"
          }
}

I went ahead and fixed the initial json you posted, there were a bunch of syntax errors:

{
	"url": "https://mydomain.com",
	"server": {
		"port": 2368,
		"host": "127.0.0.1"
	},
	"database": {
		"client": "mysql",
		"connection": {
			"host": "localhost",
			"user": "ghost-456",
			"password": "REDACTED",
			"port": 3306,
			"database": "ghost_production"
		}
	},
	"mail": {
		"from": "vanessa <noreply @ DOMAIN>",
		"transport": "SMTP",
		"options": {
			"service": "Mailgun",
			"host": "smtp.mailgun.org",
			"port": 465,
			"secureConnection": true,
			"auth": {
				"user": "TKTKTK@gmail.com",
				"pass": "REDACTED"
			}
		}
	},
	"transport": "Direct",
	"logging": {
		"transports": [
			"file",
			"stdout"
		]
	},
	"process": "systemd",
	"paths": {
		"contentPath": "/var/www/ghost/content"
	}
}