Yeah, it’s pretty easy to achieve! Just go to Ghost Admin > Labs and download your routes.yaml file from Routes.
There, you’ll find something like and you add your podcast collection in:
collections:
/:
permalink: /{slug}/
filter: tag:-podcast
template: index
/podcast/:
permalink: /podcast/
filter: tag:podcast
template: podcasts
This creates a new collection which you can think as a collection of posts where your podcasts will be. It tells the homepage collection to not include any posts tagged with podcast, and for yoursite.com/podcast/ to only include all posts tagged with the tag podcast.
It will also use podcasts.hbs in your theme as the template for the /podcast/ page, so you might want to add that in.